Pharmacotherapeutic group: G03GA05 - gonadotropin. Indications for use drugs: female infertility frosty hypo-or normohonadotropnoyu ovarian failure - follicular growth stimulation, controlled ovarian hyperstimulation for induction of multiple follicular growth during assisted reproductive technology (ART), fertilization in vitro, and intraplazmatychniy sperm injection. Side effects and complications in the use of drugs: nausea, vomiting, abdominal pain, constipation, diarrhea, flatulence, headache, moderate increase in ovarian formation of ovarian cysts, breast compression c-m ovarian hyperstimulation (lower abdomen pain, nausea, diarrhea, a slight increase in ovarian development of ovarian cysts of large cysts, ascites, hidrotoraksu, weight gain, increased risk of ectopic and multiple pregnancy), dry skin, hair loss, AR (fever, chills, rash, frosty hyperemia) locally pain, swelling, rash, itching, irritation at the injection site preparation; thromboembolism, myalgia, arthralgia, weakness. The main pharmaco-therapeutic effects: follicle-stimulating action, stimulates growth and maturation of ovarian follicles, increases estrogen stimulates endometrial proliferation, no progestin action. Method of production of drugs: lyophilized powder for making Mr injection of 75 IU in vial., Lyophillisate for frosty injection of 75 IU, 150 IU in vial. The main pharmaco-therapeutic action: stimulant ovulation. Indications for use drugs: anovulatory cycle (including c-m polycystic ovaries) in women who are not sensitive to treatment Clomifenum citrate; of assisted reproductive technologies (ART). Dosing and Administration of drugs: optimal dose and duration of treatment determine the results of ultrasound ovarian estrogen frosty studies in blood and urine, and clinical frosty anovulatory cycle (including c-m polycystic ovaries) - 75-150 IU / day, first 7 days cycle in women during menstruation can start treatment with a dose of 37.5 IU with increasing need for up to 75 IU MDD - 225 IU; interval between courses Trinitroglycerin 7 or 14 days if no adequate response after four frosty of treatment, should resume in the next cycle of the drug in doses greater than in here cycles, but does not exceed the highest daily dose - 450 IU in obtaining adequate response 24-48 h after introduction of last dose administered chorionic gonadotropin in a dose of 5 000-10 000 IU daily injections of hCG recommend koyitus patient and repeat it the next day, women who carry out controlled ovarian stimulation using Essential Amino Acids reproductive techniques - 150-225 IU / day starting from 2-3-day cycle of treatment lasts until sufficient follicle development, the degree of follicle measured at concentrations of estrogen in plasma and frosty or using ultrasonic testing, dosage is determined individually, not above 450 frosty here day; follicle development achieved on the 10-day treatment (within 5-20 frosty 24-48 h after entering the last dose administered chorionic gonadotropin in a dose of 5 000-10 000 IU for stimulation of follicle rupture, the drug is introduced in the Right Upper Quadrant m or subcutaneously. The human menopausal gonadotropin. Contraindications to the use of drugs: hypersensitivity to the drug, Posterior Cruciate Ligament levels of follicle stimulating hormone in primary ovarian failure, thyroid gland and adrenal glands at the stage of decompensation, infertility is not associated with ovarian frosty metrorahiya, bleeding unclear etiology, pituitary tumor, cancer ovarian, uterine or breast cancer, ovarian increase (only frosty polycystic ovaries), pregnancy, lactation. Dosing and Administration of drugs: injected V / m or subcutaneously, the duration of treatment in each case depends on individual patient characteristics (level of estradiol and ultrasound data) in order to stimulate growth of follicles dose selected individually, depending on frosty response and adjusted after the ultrasound and blood estrogen levels, with inflated drug doses observed single or double-headed growth ovarian treatment, usually starting with a dose of 75-150 IU / day in the absence of ovarian response dose gradually increasing to register increase in estrogen blood or follicular growth, this dose is kept until the concentration reaches preovulyatornoho estrogen levels, the rapid increase in estrogen levels at the beginning of stimulation dose should be reduced, for ovulation induction in 1-2 days after the last injection administered once SFHE 5000 -10 000 IU lHH (in / m).
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